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As the Drug Discovery Engine for ALS, the ALS Therapy Development Institute (ALS TDI) discovers and invents ALS treatments and partners to advance them into clinical trials. It is the first and largest nonprofit biotech focused 100% on ALS research. ALS TDI incorporates all aspects of drug discovery under one roof to find treatments as quickly as possible. Located in Watertown, MA, ALS TDI employs researchers with over 300 years of combined experience and expertise across all areas of drug discovery. ALS TDI is recognized as an international leader in preclinical and translational ALS research, and partners with pharmaceutical companies and biotechs around the world. Awarded the highest nonprofit rating – four stars – on Charity Navigator, ALS TDI spends 87 cents of every dollar raised on finding effective treatments and cures for ALS.

Connecticut Children's Medical Center is dedicated to improving the physical and emotion health of children. The people of Connecticut Children's Medical Center embrace a comprehensive view of child health and strive for preeminence in helping each child reach for and achieve maximum potential and independence. We stress excellence, innovation and leadership in providing the highest quality service, education and research.

Our mission is to facilitate, advocate and promote education, support and research for the prevention, treatment and cure of liver disease.

Shatterproof is a national nonprofit organization dedicated to reversing the addiction crisis in the United States.

The mission of the Pitt Hopkins Research Foundation (PHRF) is to support research dedicated to finding a treatment, and hopefully an eventual cure of Pitt Hopkins and other similar disorders. Made up of families for families, the PHRF is also dedicated to supporting PTHS children with resource recommendations, parental support and the latest medical information.Our board and officers are parents and professionals who volunteer their time, so that over 93% of all funds raised and donated go to finding a cure. Our goal is to find a treatment as quickly as possible that will help give our children fuller, higher functioning lives.

Food Allergy Research & Education (FARE) works on behalf of the 15 million Americans with food allergies, including all those at risk for life-threatening anaphylaxis. This potentially deadly disease affects 1 in 13 children in the United States – or roughly two in every classroom. FARE is a 501(c)(3) nonprofit organization that was formed in 2012 as the result of a merger between the Food Allergy & Anaphylaxis Network and the Food Allergy Initiative. FARE’s mission is to ensure the safety and inclusion of individuals with food allergies while relentlessly seeking a cure.

At the Fanconi Cancer Foundation (FCF), we are committed to the advancement of FA research in an unwavering pursuit for better treatments, and ultimately a cure, for FA and FA-associated cancers. We offer support, education, and resources to families facing FA to help foster hope across the globe.

Wellness in the Schools is a national non-profit that teaches kids healthy habits to learn and live better. We partner with public schools to provide nutrition and fitness education, healthy scratch-cooked meals and active recess periods. Our approach improves student outcomes and drives systemic, long-term change, shifting school cultures.

Mercy Home offers abused or neglected youth who seek a new beginning hope and promise of a healthy and successful future, safety, respect and opportunities for growth. Mercy Home seeks benefactors who believe in the miracle of God's mercy and in the integrity of those who care for the health and safety of our children. Mercy Home is committed to raising public awareness of the plight of all of society's at-risk youth in order to encourage support of programs that would enable them to begin their own process of healing.

Little City is dedicated to serving children and adults with intellectual and developmental disabilities by providing the best options and opportunities to live safely, learn continuously, explore creatively and work productively throughout their lifetime. By inspiring, advocating and pursuing success with passion and purpose, lives are changed through hope, happiness, and optimism.

The Night Ministry was created out of diverse religious traditions to build relationships with vulnerable youth and adults on the nighttime streets. Today, we build relationships in a variety of settings. Through these relationships and the provision of housing, health, outreach, spiritual, and social services, we seek to empower people of all ages to meet their own needs. Recognizing the uniqueness, dignity, and value of each person, we accept individuals as they are, in an affirming and compassionate manner. We call the larger community to the same mission. Since 1976, The Night Ministry, a non-profit, non-denominational social service organization has served people at difficult crossroads in their lives. We work to build relationships with youth and adults we serve - regardless of race, ethnicity, religion, sexual orientation, gender identification or social status. We offer concrete services in compassionate, accepting environments. Through our two programs, Outreach & Health, and Youth Services, we provide basic resources, free healthcare, housing and supportive services for youth, referrals to other resources, and more. We do not proselytize, evangelize or espose any particular faith tradition. Our ministry is one of serving. The Night Ministry serves homeless and runaway youth, working poor adults, uninsured and underinsured individuals seeking medical assistance and others Staff and volunteers work to build non-judgmental relationships aimed at empowering individuals to meet their own needs. We try to help those we serve find and use their own strengths and resources.

METAvivor is dedicated to the specific fight of women and men living with stage 4 metastatic breast cancer. At the time of METAvivor’s founding, no organization was dedicated to funding research for the disease and no patient groups were speaking out about the dearth of stage 4 cancer research. While more and more people have taken up the cry for more stage 4 research, METAvivor remains the sole US organization dedicated to awarding annual stage 4 breast cancer research.