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Smile Train is an international children’s charity with a sustainable approach to a single, solvable problem: cleft lip and palate. Millions of children in developing countries with unrepaired clefts live in shame, but more importantly, have difficulty eating, breathing and speaking. Cleft repair surgery is simple, and the transformation is immediate. Our sustainable model provides training and funding to empower local doctors in 85+ developing countries to provide 100%-free cleft repair surgery in their communities. We use the “teach a man to fish” model focusing on training local doctors to perform cleft repairs in their communities. Those doctors then go on to train other doctors creating a long-term, sustainable system. Patients see their smile for the first time, parents cry tears of joy, lives and communities are changed forever. As a result of our efficiency and with the support of our donors and partners around the world, Smile Train has transformed the lives of more than one million children by giving them the power of a smile -- that's roughly 350 surgeries a day and 128,000+ every year.  

Your support makes it possible for us to offer high-quality patient education from top scleroderma experts, facilitate patient support groups and fund promising research.

Golden Heart Ranch (GHR) provides young adults with intellectual and development disabilities opportunities to reach their fullest potentials and enjoy meaningful, satisfying and joyful lives. We are an inclusive community where all young adults learn, work and create lifelong friendships in a supportive and caring environment.

With the success of the Salk vaccine in the mid 1950s, the March of Dimes turned its focus on birth defects, low birth weight and infant death. Over the past 75 years, March of Dimes' cutting edge research and innovative programs have saved millions of babies from death or disability. We are committed to educating medical professionals and the public, supporting research, providing comfort and support to families in NICUs, and advocating for moms and babies. All mothers and babies deserve access to the tools they need for the success of their families, so that the future is brighter for all. Every Mom. Every Baby.

Through education and outreach we support those affected by Lewy body dementias, and promote research for a cure.

UMDF's mission is to promote research and education for the diagnosis, treatment and cure of mitochondrial disorders and provide support to affected individuals and families.

The Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 dedicated to finding treatments and a cure for Charcot-Marie-Tooth disease (CMT) and related hereditary neuropathies while providing support and extensive information for those living with CMT and their families. HNF promotes and supports innovative therapeutic driven research.

The mission of Southeastern Guide Dogs is to create and nurture a partnership between a visually impaired individual and a guide dog, facilitating life's journey with mobility, independence and dignity.

The mission of Joslin Diabetes Center is to prevent, treat and cure diabetes. Our vision is a world free of diabetes and its complications.

Paralyzed Veterans of America (PVA), a congressionally chartered veterans service organization founded in 1946, has developed a unique expertise on a wide variety of issues involving the special needs of our members veterans of the armed forces who have experienced spinal cord injury or dysfunction. PVA will use that expertise to be the leading advocate for: - Quality health care for our members - Research and education addressing spinal cord injury and dysfunction - Benefits available as a result of our members military service - Civil rights and opportunities which maximize the independence of our members and all people with disabilities. For more than 60 years, PVA has fought for our veterans who answered the call when our nation asked for their service . . . and in return, they have given up their freedoms to protect ours.

Hospice Austin is a nonprofit organization that eases the physical, emotional and spiritual pain of any person in our community facing the final months of a serious illness by providing expert and compassionate care, education and bereavement support.

Their mission is to provide care, support, advocacy, and education to people in Erie County impacted by serious illness and loss. Also known as Hospice & Palliative Care Buffalo.